For certain adults with advanced kidney cancer (renal cell carcinoma)
OPDIVO® (nivolumab) is a prescription medicine used in combination with YERVOY® (ipilimumab) to treat adults with kidney cancer (renal cell carcinoma) in certain people when your cancer has spread (advanced renal cell carcinoma) and you have not already had treatment for your advanced RCC.
It is not known if OPDIVO is safe and effective in children younger than 12 years of age with melanoma or MSI-H or dMMR metastatic colorectal cancer.
It is not known if OPDIVO is safe and effective in children for the treatment of any other cancers.
A CHANCE TO LI E LONGERTM
For certain adults with advanced kidney cancer (renal cell carcinoma)
OPDIVO® (nivolumab) + YERVOY® (ipilimumab): the first and only combination of 2 immunotherapies can be taken first
A diagnosis of advanced kidney cancer, or renal cell carcinoma (RCC), can come as a shock. But, with study results like these, you can stay positive with good reason.
The OPDIVO + YERVOY clinical trial
About the Clinical Trial
Clinical Trial Results
In the primary analysis at 2 years
(25.2 months)
67% of patients on OPDIVO + YERVOY were alive
compared
to 56% of patients being alive on SUTENT.
OPDIVO + YERVOY was proven to lower the risk of dying
by 37% compared to SUTENT.
Half of the patients on SUTENT were alive at 25.9 months
compared to more than half being alive on OPDIVO + YERVOY.
At 5 years (Follow-up data)
of patients were alive
on OPDIVO + YERVOY
of patients were alive
on SUTENT
OPDIVO + YERVOY was shown to lower the risk of
dying by 32% compared to SUTENT.
Half of the patients on SUTENT were alive at
26.6 months compared to half being alive on
OPDIVO + YERVOY at 47 months.
A chance for tumors to disappear completely
In the primary analysis at 2 years (25.2 months), the length of time patients lived without tumors worsening was 11.6 months for OPDIVO + YERVOY and 8.4 months for SUTENT. There was no meaningful difference between the two treatments
†The disappearance of many measurable tumors in response to treatments does not necessarily mean the cancer has been cured.
Ask your doctor about your risk factor assessment and if OPDIVO + YERVOY is right for you.
OPDIVO + YERVOY will not work for everyone. Individual results may vary.
While your doctor may perform a PD-L1 (programmed death ligand-1) biomarker test, OPDIVO + YERVOY is FDA-approved to treat this condition regardless of your test results.
SELECT IMPORTANT FACTS
What are the possible serious side effects of OPDIVO and OPDIVO + YERVOY?
OPDIVO and YERVOY can cause problems that can sometimes become serious or life-threatening and can lead to death. Serious side effects may include:
- Lung problems
- Intestinal problems
- Liver problems
- Hormone gland problems
- Kidney problems
- Skin problems
- Eye problems
- Problems in other organs and tissues
- Severe infusion reactions
- Complications, including
graft-versus-host disease (GVHD), of bone marrow(stem cell) transplant that uses donor stem cells (allogeneic)
These are not all of the signs and symptoms of immune system problems that can happen with OPDIVO and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include:
- Chest pain, irregular heartbeat, shortness of breath, swelling of ankles
- Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
- Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
- Persistent or severe muscle pain or weakness, muscle cramps
- Low red blood cells, bruising
What are the most common side effects of OPDIVO and OPDIVO + YERVOY?
The most common side effects of OPDIVO when used in combination with YERVOY include:
- feeling tired
- diarrhea
- rash
- itching
- nausea
- pain in muscles, bones, and joints
- fever
- cough
- decreased appetite
- vomiting
- stomach-area (abdominal) pain
- shortness of breath
- upper respiratory tract infection
- headache
- low thyroid hormone levels (hypothyroidism)
- constipation
- decreased weight
- dizziness